Fig. 7From: Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancerProposed model of PRMT3-mediated metabolic reprogramming in pancreatic cancer cells. PRMT3 methylates GAPDH at arginine 248 to promote glycolysis and mitochondrial respiration simultaneously in cancer cells. Double blockade of glycolysis and mitochondrial respiration could be a novel strategy for the treatment of PRMT3-overexpressing pancreatic cancerBack to article page