Table 2 Univariate analysis of donor-related characteristics on transplant outcomes
Risk factors | II–IV aGVHD | III–IV aGVHD | Chronic GVHD | Extensive cGVHD | FFS | OS |
|---|---|---|---|---|---|---|
Relationship | 100d estimated cumulative incidence | 2-year estimated cumulative incidence or probability | ||||
 Paternal donor | 39.9% ± 0.1% | 9.4%±0.0% | 27.1%±0.1% | 10.3%±0.1% | 82.8%±2.7% | 86.5% ± 2.5% |
 Maternal donor | 31.9% ± 0.5% | 14.9% ± 0.3% | 44.3% ± 0.6% | 11.9% ± 0.3% | 86.7% ± 5.1% | 87.1% ± 4.9% |
 Sibling donor | 25.3% ± 0.2% | 5.5% ± 0.1% | 29.5% ± 0.3% | 7.5% ± 0.1% | 80.8% ± 4.2% | 84.3% ± 3.9% |
 Offspring donor | 20.7% ± 0.6% | 3.4% ± 0.1% | 40.6% ± 1.2% | 7.2% ± 0.2% | 92.5% ± 5.1% | 92.5% ± 5.1% |
 P | 0.026 | 0.202 | 0.175 | 0.843 | 0.508 | 0.706 |
 Paternal donor | 39.9% ± 0.1% | 9.4% ± 0.0% | 27.1% ± 0.1% | 10.3% ± 0.1% | 82.8% ± 2.7% | 86.5% ± 2.5% |
 Maternal donor | 31.9% ± 0.5% | 14.9% ± 0.3% | 44.3% ± 0.6% | 11.9% ± 0.3% | 86.7% ± 5.1% | 87.1% ± 4.9% |
 P | 0.272 | 0.282 | 0.046 | 0.780 | 0.937 | 0.755 |
 Sibling donor | 25.3% ± 0.2% | 5.5% ± 0.1% | 29.5% ± 0.3% | 7.5% ± 0.1% | 80.8% ± 4.2% | 84.3% ± 3.9% |
 Offspring donor | 20.7% ± 0.6% | 3.4% ± 0.1% | 40.6% ± 1.2% | 7.2% ± 0.2% | 92.5% ± 5.1% | 92.5% ± 5.1% |
 P | 0.697 | 0.670 | 0.333 | 0.858 | 0.130 | 0.252 |
 Paternal donor | 39.9% ± 0.1% | 9.4% ± 0.0% | 27.1% ± 0.1% | 10.3% ± 0.1% | 82.8% ± 2.7% | 86.5% ± 2.5% |
 Sibling donor | 25.3% ± 0.2% | 5.5% ± 0.1% | 29.5% ± 0.3% | 7.5% ± 0.1% | 80.8% ± 4.2% | 84.3% ± 3.9% |
 P | 0.011 | 0.238 | 0.699 | 0.445 | 0.478 | 0.475 |
Donor age | ||||||
 < 30 | 27.2% ± 0.2% | 4.9% ± 0.0% | 35.0% ± 0.3% | 9.2% ± 0.1% | 85.8% ± 3.5% | 88.2% ± 3.2% |
 ≥ 30 | 36.3% ± 0.1% | 10.0% ± 0.0% | 29.1% ± 0.1% | 9.7% ± 0.0% | 82.3% ± 2.4% | 85.6% ± 2.2% |
 P | 0.104 | 0.106 | 0.194 | 0.815 | 0.538 | 0.659 |
 < 40 | 32.0% ± 0.1% | 7.5% ± 0.0% | 28.9% ± 0.1% | 7.5% ± 0.0% | 86.1% ± 2.3% | 88.4% ± 2.1% |
 ≥ 40 | 37.1% ± 0.2% | 10.6% ± 0.1% | 32.9% ± 0.2% | 12.5% ± 0.1% | 79.0% ± 3.5% | 83.4% ± 3.2% |
 P | 0.383 | 0.303 | 0.463 | 0.162 | 0.104 | 0.187 |
Donor sex | ||||||
 Male | 35.9% ± 0.1% | 8.1% ± 0.0% | 28.3% ± 0.1% | 9.1% ± 0.0% | 82.9% ± 2.3% | 86.0% ± 2.2% |
 Female | 27.7% ± 0.2% | 10.6% ± 0.1% | 37.8% ± 0.3% | 10.8% ± 0.1% | 84.3% ± 3.9% | 87.1% ± 3.5% |
 P | 0.137 | 0.459 | 0.144 | 0.666 | 0.901 | 0.871 |
Donor-recipient sex | ||||||
 Male-male | 36.0% ± 0.1% | 7.0% ± 0.0% | 27.2% ± 0.1% | 9.7% ± 0.1% | 79.0% ± 3.3% | 81.4% ± 3.2% |
 Female-male | 22.6% ± 0.3% | 9.4% ± 0.2% | 40.3% ± 0.6% | 17.2% ± 0.3% | 87.4% ± 4.9% | 92.3% ± 3.7% |
 Male-female | 35.7% ± 0.2% | 9.5% ± 0.1% | 30.0% ± 0.2% | 8.6% ± 0.1% | 88.2% ± 3.0% | 92.1% ± 2.5% |
 Female-female | 34.1% ± 0.6% | 12.2% ± 0.3% | 34.7% ± 0.7% | 2.6% ± 0.1% | 80.5 ± 6.2% | 80.3% ± 6.2% |
 P | 0.324 | 0.711 | 0.459 | 0.175 | 0.251 | 0.030 |
HLA match | ||||||
 3/6 | 36.8% ± 0.1% | 5.0% ± 0.3% | 28.9% ± 0.1% | 7.6% ± 0.0% | 83.7% ± 2.2% | 86.8% ± 2.0% |
 4/6 | 27.4% ± 0.3% | 6.5% ± 0.1% | 31.7% ± 0.4% | 16.4% ± 0.3% | 79.3% ± 5.8% | 82.6% ± 5.1% |
 5-6/6 | 10.0% ± 0.5% | 9.4% ± 0.0% | 54.5% ± 1.7% | 17.5% ± 0.9% | 88.2% ± 8.0% | 89.1% ± 7.3% |
 P | 0.019 | 0.616 | 0.307 | 0.096 | 0.578 | 0.551 |
ABO blood type | ||||||
 Match | 30.8% ± 0.1% | 4.7% ± 0.0% | 31.4% ± 0.1% | 8.5% ± 0.0% | 82.1% ± 2.8% | 86.5% ± 2.5% |
 Minor mismatch | 42.0% ± 0.3% | 17.3% ± 0.2% | 32.7% ± 0.3% | 9.9% ± 0.1% | 84.7% ± 4.1% | 87.4% ± 3.7% |
 Major mismatch | 32.3% ± 0.3% | 9.9% ± 0.1% | 20.7% ± 0.3% | 10.0% ± 0.2% | 87.8% ± 4.1% | 87.8% ± 4.1% |
 Bidirectional mismatch | 38.5% ± 1.0% | 11.5% ± 0.4% | 43.5% ± 1.1% | 15.6% ± 0.5% | 75.7% ± 8.8% | 77.0% ± 8.3% |
 P | 0.415 | 0.007 | 0.162 | 0.668 | 0.490 | 0.517 |