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Table 2 Univariate analysis of donor-related characteristics on transplant outcomes

From: Who is the best haploidentical donor for acquired severe aplastic anemia? Experience from a multicenter study

Risk factors II–IV aGVHD III–IV aGVHD Chronic GVHD Extensive cGVHD FFS OS
Relationship 100d estimated cumulative incidence 2-year estimated cumulative incidence or probability
 Paternal donor 39.9% ± 0.1% 9.4%±0.0% 27.1%±0.1% 10.3%±0.1% 82.8%±2.7% 86.5% ± 2.5%
 Maternal donor 31.9% ± 0.5% 14.9% ± 0.3% 44.3% ± 0.6% 11.9% ± 0.3% 86.7% ± 5.1% 87.1% ± 4.9%
 Sibling donor 25.3% ± 0.2% 5.5% ± 0.1% 29.5% ± 0.3% 7.5% ± 0.1% 80.8% ± 4.2% 84.3% ± 3.9%
 Offspring donor 20.7% ± 0.6% 3.4% ± 0.1% 40.6% ± 1.2% 7.2% ± 0.2% 92.5% ± 5.1% 92.5% ± 5.1%
P 0.026 0.202 0.175 0.843 0.508 0.706
 Paternal donor 39.9% ± 0.1% 9.4% ± 0.0% 27.1% ± 0.1% 10.3% ± 0.1% 82.8% ± 2.7% 86.5% ± 2.5%
 Maternal donor 31.9% ± 0.5% 14.9% ± 0.3% 44.3% ± 0.6% 11.9% ± 0.3% 86.7% ± 5.1% 87.1% ± 4.9%
P 0.272 0.282 0.046 0.780 0.937 0.755
 Sibling donor 25.3% ± 0.2% 5.5% ± 0.1% 29.5% ± 0.3% 7.5% ± 0.1% 80.8% ± 4.2% 84.3% ± 3.9%
 Offspring donor 20.7% ± 0.6% 3.4% ± 0.1% 40.6% ± 1.2% 7.2% ± 0.2% 92.5% ± 5.1% 92.5% ± 5.1%
P 0.697 0.670 0.333 0.858 0.130 0.252
 Paternal donor 39.9% ± 0.1% 9.4% ± 0.0% 27.1% ± 0.1% 10.3% ± 0.1% 82.8% ± 2.7% 86.5% ± 2.5%
 Sibling donor 25.3% ± 0.2% 5.5% ± 0.1% 29.5% ± 0.3% 7.5% ± 0.1% 80.8% ± 4.2% 84.3% ± 3.9%
P 0.011 0.238 0.699 0.445 0.478 0.475
Donor age
 < 30 27.2% ± 0.2% 4.9% ± 0.0% 35.0% ± 0.3% 9.2% ± 0.1% 85.8% ± 3.5% 88.2% ± 3.2%
 ≥ 30 36.3% ± 0.1% 10.0% ± 0.0% 29.1% ± 0.1% 9.7% ± 0.0% 82.3% ± 2.4% 85.6% ± 2.2%
P 0.104 0.106 0.194 0.815 0.538 0.659
 < 40 32.0% ± 0.1% 7.5% ± 0.0% 28.9% ± 0.1% 7.5% ± 0.0% 86.1% ± 2.3% 88.4% ± 2.1%
 ≥ 40 37.1% ± 0.2% 10.6% ± 0.1% 32.9% ± 0.2% 12.5% ± 0.1% 79.0% ± 3.5% 83.4% ± 3.2%
P 0.383 0.303 0.463 0.162 0.104 0.187
Donor sex
 Male 35.9% ± 0.1% 8.1% ± 0.0% 28.3% ± 0.1% 9.1% ± 0.0% 82.9% ± 2.3% 86.0% ± 2.2%
 Female 27.7% ± 0.2% 10.6% ± 0.1% 37.8% ± 0.3% 10.8% ± 0.1% 84.3% ± 3.9% 87.1% ± 3.5%
P 0.137 0.459 0.144 0.666 0.901 0.871
Donor-recipient sex
 Male-male 36.0% ± 0.1% 7.0% ± 0.0% 27.2% ± 0.1% 9.7% ± 0.1% 79.0% ± 3.3% 81.4% ± 3.2%
 Female-male 22.6% ± 0.3% 9.4% ± 0.2% 40.3% ± 0.6% 17.2% ± 0.3% 87.4% ± 4.9% 92.3% ± 3.7%
 Male-female 35.7% ± 0.2% 9.5% ± 0.1% 30.0% ± 0.2% 8.6% ± 0.1% 88.2% ± 3.0% 92.1% ± 2.5%
 Female-female 34.1% ± 0.6% 12.2% ± 0.3% 34.7% ± 0.7% 2.6% ± 0.1% 80.5 ± 6.2% 80.3% ± 6.2%
P 0.324 0.711 0.459 0.175 0.251 0.030
HLA match
 3/6 36.8% ± 0.1% 5.0% ± 0.3% 28.9% ± 0.1% 7.6% ± 0.0% 83.7% ± 2.2% 86.8% ± 2.0%
 4/6 27.4% ± 0.3% 6.5% ± 0.1% 31.7% ± 0.4% 16.4% ± 0.3% 79.3% ± 5.8% 82.6% ± 5.1%
 5-6/6 10.0% ± 0.5% 9.4% ± 0.0% 54.5% ± 1.7% 17.5% ± 0.9% 88.2% ± 8.0% 89.1% ± 7.3%
P 0.019 0.616 0.307 0.096 0.578 0.551
ABO blood type
 Match 30.8% ± 0.1% 4.7% ± 0.0% 31.4% ± 0.1% 8.5% ± 0.0% 82.1% ± 2.8% 86.5% ± 2.5%
 Minor mismatch 42.0% ± 0.3% 17.3% ± 0.2% 32.7% ± 0.3% 9.9% ± 0.1% 84.7% ± 4.1% 87.4% ± 3.7%
 Major mismatch 32.3% ± 0.3% 9.9% ± 0.1% 20.7% ± 0.3% 10.0% ± 0.2% 87.8% ± 4.1% 87.8% ± 4.1%
 Bidirectional mismatch 38.5% ± 1.0% 11.5% ± 0.4% 43.5% ± 1.1% 15.6% ± 0.5% 75.7% ± 8.8% 77.0% ± 8.3%
P 0.415 0.007 0.162 0.668 0.490 0.517
  1. aGVHD acute graft-versus-host disease, cGVHD chronic graft-versus-host disease, FFS failure-free survival, OS overall survival.