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Table 2 Pharmacokinetics of LSD1 inhibitor GSK2879552 in mice

From: LSD1/KDM1A inhibitors in clinical trials: advances and prospects

  Cmax (ng/mL) Tmax (h) AUC(0-last) (ng*h/mL or ng*h/g) AUC(0-inf) (hr*ng/mL or hr*ng/g) DNAUC(0-last) (ng*h/mL/mg/k g) T1/2 (h) AUC_%Extrap_pred (%)
Blood 720 0.25 852.7 903.2 171 1.9 5.6
Tumor 354.7 0.5 2321.6 2693.0 464 8.4 13.8