Fig. 3
From: Targeting cancers through TCR-peptide/MHC interactions
Schematics of TCR-T immunotherapy in current clinical settings. Peripheral blood mononuclear cell (PBMC) were isolated from the cancer patients by leukapheresis and transduced with tumor antigen-specific TCR-containing lentivirus, retrovirus, mRNA, or transposon vector. The tumor antigen-specific TCRs-transduced T cells were then expanded in vitro to a great number before infusion back into the patients