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Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

Fig. 7

Effect of anti-CD47 and anti-PD-L1 treatment on tumor-infiltrating immune cells in PDAC mouse models. Panc02 or MPC-83 cells were transplanted to C57BL/6 or KM mice. And the tumor-bearing mice were treated as in Fig. 6 c and d. Cell suspensions were prepared from the peripheral blood, spleen, and pancreatic tumor tissues from tumor-bearing mice and analyzed by flow cytometry and bulk RNA-seq. ac Quantification of CD8+PD-1+ T lymphocytes in the Panc02 tumor model in the indicated tissues. df Quantification of CD8+ PD-1+ T lymphocytes in the MPC-83 tumor model in the indicated tissues. g Heatmap from RNA-seq displaying expression of select genes in each tumor-bearing mouse group

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