The role of cancer-derived microRNAs in cancer immune escape

Table 4 Cancer cells-derived miRNAs regulating immune evasion via exosomes or vehicles

Immune cells regulated by cancer cells-derived exosomal miRNAs	miRNAs	Cancer cell types	Effects on anti-cancer immune response	Ref.
Effector T cells	miR-690	Melanoma	Immunosuppressive	[125]
	miR-24-3p	NPC	Immunosuppressive	[126]
	miR-891a	NPC	Immunosuppressive	[126]
	miR-106a-5p	NPC	Immunosuppressive	[126]
	miR-20a-5p	NPC	Immunosuppressive	[126]
	miR-1908	NPC	Immunosuppressive	[126]
TAMs	miR-222-3p	EOC	Immunosuppressive	[127]
	miR-940	EOC	Immunosuppressive	[128]
	miR-21-3p	EOC	Immunosuppressive	[129]
	miR-125b-5p	EOC	Immunosuppressive	[129]
	miR-181d-5p	EOC	Immunosuppressive	[129]
	miR-21	Head and neck cancer	Immunosuppressive	[130]
	miR-1246	Colon cancer	Immunosuppressive	[131]
	miR-16	Breast cancer	Immunostimulatory	[132]
MDSCs	miR-107	Gastric cancer	Immunosuppressive	[133]
	miR-21	OSCC	Immunosuppressive	[134]
	miR-21	Glioma	Immunosuppressive	[135]
	miR-10a	Glioma	Immunosuppressive	[135]
	miR-29a	Glioma	Immunosuppressive	[136]
	miR-92a	Glioma	Immunosuppressive	[136]
	miR-155	CLL	Immunosuppressive	[137]
CAFs	miR-27a	Gastric cancer	Immunosuppressive	[138]
	miR-1247-3p	HCC	Immunosuppressive	[139]
	miR-21	HCC	Immunosuppressive	[140]

NPC nasopharyngeal carcinoma, TAM tumor-associated macrophage, EOC epithelial ovarian cancer, MDSC myeloid-derived suppressor cell, OSCC oral squamous cell carcinoma, CLL chronic lymphocytic leukemia, CAF cancer-associated fibroblast, HCC hepatocellular carcinoma

ISSN: 1756-8722