From: Treatment of mantle cell lymphoma in Asia: a consensus paper from the Asian Lymphoma Study Group
Agent | Class | Availability in Asia |
---|---|---|
Cyclophosphamide | Alkylating agent | Widely available |
Doxorubicin | Anthracycline | Widely available |
Vincristine | Microtubule assembly blocker | Widely available |
Cytarabine | DNA polymerase inhibitor | Cytarabine is the backbone of chemotherapy regimens in Asia |
Cisplatin | DNA replication inhibitor | Widely available |
Lenalidomide | Immunomodulatory agent | Approved and reimbursed in limited countries |
Bendamustine | Alkylating agent | Approved and reimbursed excluding Korea |
Rituximab | Monoclonal antibody | Approved and reimbursed as R-CHOP or R-HyperCVAD R-maintenance is limitedly available |
Temsirolimus | mTOR inhibitor | Rarely used outside of Asia |
Bortezomib | Proteasome inhibitor | Approved and reimbursed for first-line use as VR-CAP |
Acalabrutinib | BTK inhibitor | Not available in Asia |
Zanubrutinib | BTK inhibitor | Not available in Asia |
Ibrutinib | BTK inhibitor | Widely approved and reimbursed for rrMCL |
Venetoclax | BH3-mimetic | Approved for MCL in limited countries |