Fig. 3

JNK inhibition cooperates with dasatinib in killing Ph⁺ B-ALL cells. a SUP-B15 cells expressing ShNC, ShJNK#1, or ShJNK#2 were treated with different concentrations of dasatinb for 24 h. Viability of these cells was then measured by the CellTiter Glo assay. b SUP-B15 cells were treated with indicated concentrations of dasatinib combined with or without JNK-IN-8 (6 μmol/L and 8 μmol/L) for 24 h. Viability of these cells was measured by the CellTiter Glo assay. c “Combination index” (CI) values were calculated at each concentration of JNK-IN-8 based on data in b and plotted, Fractional inhibition abbreviated as Fa. Data are presented as mean ± SD