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Table 1 Inhibitory immune checkpoint roles of VISTA

From: VISTA: an immune regulatory protein checking tumor and immune cells in cancer immunotherapy

Cancer type Research object VISTA expression Reference
Melanoma Samples from patients with untreated metastatic melanoma CD68+ macrophages Blando et al. [17]
B16-BL6 melanoma cells Tumor-associated myeloid cells Xu et al. [18]
Patient samples, melanoma cell lines Melanoma cells Rosenbaum et al. [19]
B16 OVA melanoma models CD8+ T cells Kondo et al. [20]
VISTA-KO mice, PD-1 KO mice, VISTA/PD-1 double KO mice T cells Liu et al. [21]
Patient samples with acquired anti-PD-1 resistance Lymphocytes Kakavand et al. [22]
Pancreatic ductal adenocarcinoma Patient samples CD68+ macrophages Blando et al. [17]
Patient samples Activated T cells Xie et al. [23]
Pancreatic tissue including pancreatic adenocarcinomas Normal ductal epithelium within the pancreas Byers et al. [24]
Prostate cancer Samples from patients with or without ipilimumab treatment Independent subsets of macrophages Gao et al. [14]
Renal cell carcinoma Patient samples Activated T cells Ni et al. [25]
Patient samples Tumor tissues, CD14+HLA-DR+ macrophages Hong et al. [26]
Non-small cell lung cancer NSCLC FFPE tumor samples NSCLC tumor and stromal cells Villarroel-Espindola et al. [13]
NSCLC FFPE tumor samples NSCLC tumor and stromal cells Hernandez-Martinez et al. [27]
Resected tissues and bronchoalveolar lavage samples Lymphocytes Brcic et al. [28]
Acute myeloid leukemia Human AML donors, AML mouse model, VISTA-KO mice Myeloid subsets and T cells Kim et al. [29]
Peripheral blood from AML patients Myeloid-derived suppressor cells Wang et al. [30]
Colorectal cancer VISTA-KO mice, CT26 colon carcinoma cell line Tumor-infiltrating leukocytes Xie et al. [15]
Ovarian cancer Patient samples, ID8 mouse ovarian cancer cell line, mice Tumor cells Mulati et al. [31]
Endometrial cancer Patient samples, OV2944-HM-1 mouse ovarian cancer cell line, mice Tumor cells, CD8+ T cells Mulati et al. [31]
Fibrosarcoma MCA105 fibrosarcoma cell lines, mice Hematopoietic cell types Wang et al. [4]
Glioma Murine glioma model, VISTA-KO mice CD4+ T cells Flies et al. [12]
  1. AML acute myeloid leukemia, FFPE formalin-fixed paraffin-embedded, KO knockout, NSCLC non-small cell lung cancer