Skip to main content

Table 3 Performance of the 7-AAb panel and AFP to detect HCC with different BCLC stages

From: Autoantibody signature in hepatocellular carcinoma using seromics

BCLC stage Detectiona Test phase (II) Validation phase (III) Test phase (II) + validation phase (III)
AFP ANN AFP + ANN AFP ANN AFP + ANN AFP ANN AFP + ANN
BCLC (0/A) vs. healthy + cirrhotic AUC 0.733 0.899 0.906 0.763 0.920 0.924 0.748 0.910 0.915
Specificity 98.7% 89.9% 92.1% 99.6% 90.1% 90.1% 99.1% 90.0% 89.3%
Sensitivity 14.3% 69.6% 73.2% 10.5% 80.7% 86.0% 12.4% 72.6% 79.6%
BCLC (0/A) vs. healthy AUC 0.732 0.937 0.947 0.759 0.942 0.946 0.745 0.940 0.947
Specificity 100.0% 93.3% 94.1% 100.0% 94.0% 94.7% 100.0% 93.4% 94.4%
Sensitivity 14.3% 76.8% 82.1% 10.5% 84.2% 86.0% 12.4% 80.5% 84.1%
BCLC (0/A) vs. cirrhotic AUC 0.736 0.844 0.846 0.772 0.880 0.884 0.753 0.860 0.862
Specificity 96.7% 97.8% 94.6% 98.8% 91.4% 91.4% 97.7% 90.8% 91.3%
Sensitivity 14.3% 55.4% 64.3% 10.5% 70.2% 75.4% 12.4% 65.5% 67.3%
BCLC (B) vs. healthy + cirrhotic AUC 0.824 0.894 0.923 0.847 0.895 0.927 0.835 0.895 0.926
Specificity 98.7% 89.4% 90.7% 99.6% 90.1% 90.1% 99.1% 90.0% 89.3%
Sensitivity 28.6% 72.8% 80.3% 33.0% 69.6% 78.3% 30.5% 71.4% 81.3%
BCLC (B) vs. healthy AUC 0.842 0.933 0.958 0.850 0.922 0.950 0.845 0.928 0.954
Specificity 100.0% 93.3% 96.3% 100.0% 91.4% 91.4% 100.0% 93.4% 93.4%
Sensitivity 28.6% 79.6% 85.0% 33.0% 78.3% 85.2% 30.5% 77.1% 85.1%
BCLC (B) vs. cirrhotic AUC 0.797 0.838 0.871 0.841 0.843 0.885 0.817 0.842 0.879
Specificity 96.7% 90.2% 94.6% 98.8% 88.9% 88.9% 97.7% 91.3% 91.3%
Sensitivity 28.6% 61.2% 68.7% 33.0% 65.2% 73.9% 30.5% 62.2% 72.5%
BCLC(C) vs. healthy + cirrhotic AUC 0.878 0.924 0.962 0.915 0.898 0.959 0.899 0.909 0.959
Specificity 98.7% 92.5% 93.4% 99.6% 96.6% 96.6% 99.1% 95.0% 94.3%
Sensitivity 42.9% 74.3% 88.6% 52.1% 70.8% 83.3% 48.2% 71.1% 85.5%
BCLC (C) vs. healthy AUC 0.899 0.956 0.985 0.923 0.923 0.974 0.912 0.938 0.979
Specificity 100.0% 92.6% 93.3% 100.0% 93.4% 94.7% 100.0% 93.0% 93.4%
Sensitivity 42.9% 82.9% 94.3% 52.1% 77.1% 87.5% 48.2% 79.5% 90.4%
BCLC (C) vs. cirrhotic AUC 0.848 0.877 0.928 0.899 0.850 0.931 0.877 0.861 0.927
Specificity 96.7% 92.4% 92.4% 98.8% 85.2% 85.2% 97.7% 90.2% 93.1%
Sensitivity 42.9% 65.7% 85.7% 52.1% 75.0% 87.5% 48.2% 71.1% 80.7%
  1. aThe diagnostic cutoff value of AFP was 400 ng/mL