Table 3 Performance of the 7-AAb panel and AFP to detect HCC with different BCLC stages
From: Autoantibody signature in hepatocellular carcinoma using seromics
BCLC stage | Detectiona | Test phase (II) | Validation phase (III) | Test phase (II) + validation phase (III) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
AFP | ANN | AFP + ANN | AFP | ANN | AFP + ANN | AFP | ANN | AFP + ANN | ||
BCLC (0/A) vs. healthy + cirrhotic | AUC | 0.733 | 0.899 | 0.906 | 0.763 | 0.920 | 0.924 | 0.748 | 0.910 | 0.915 |
Specificity | 98.7% | 89.9% | 92.1% | 99.6% | 90.1% | 90.1% | 99.1% | 90.0% | 89.3% | |
Sensitivity | 14.3% | 69.6% | 73.2% | 10.5% | 80.7% | 86.0% | 12.4% | 72.6% | 79.6% | |
BCLC (0/A) vs. healthy | AUC | 0.732 | 0.937 | 0.947 | 0.759 | 0.942 | 0.946 | 0.745 | 0.940 | 0.947 |
Specificity | 100.0% | 93.3% | 94.1% | 100.0% | 94.0% | 94.7% | 100.0% | 93.4% | 94.4% | |
Sensitivity | 14.3% | 76.8% | 82.1% | 10.5% | 84.2% | 86.0% | 12.4% | 80.5% | 84.1% | |
BCLC (0/A) vs. cirrhotic | AUC | 0.736 | 0.844 | 0.846 | 0.772 | 0.880 | 0.884 | 0.753 | 0.860 | 0.862 |
Specificity | 96.7% | 97.8% | 94.6% | 98.8% | 91.4% | 91.4% | 97.7% | 90.8% | 91.3% | |
Sensitivity | 14.3% | 55.4% | 64.3% | 10.5% | 70.2% | 75.4% | 12.4% | 65.5% | 67.3% | |
BCLC (B) vs. healthy + cirrhotic | AUC | 0.824 | 0.894 | 0.923 | 0.847 | 0.895 | 0.927 | 0.835 | 0.895 | 0.926 |
Specificity | 98.7% | 89.4% | 90.7% | 99.6% | 90.1% | 90.1% | 99.1% | 90.0% | 89.3% | |
Sensitivity | 28.6% | 72.8% | 80.3% | 33.0% | 69.6% | 78.3% | 30.5% | 71.4% | 81.3% | |
BCLC (B) vs. healthy | AUC | 0.842 | 0.933 | 0.958 | 0.850 | 0.922 | 0.950 | 0.845 | 0.928 | 0.954 |
Specificity | 100.0% | 93.3% | 96.3% | 100.0% | 91.4% | 91.4% | 100.0% | 93.4% | 93.4% | |
Sensitivity | 28.6% | 79.6% | 85.0% | 33.0% | 78.3% | 85.2% | 30.5% | 77.1% | 85.1% | |
BCLC (B) vs. cirrhotic | AUC | 0.797 | 0.838 | 0.871 | 0.841 | 0.843 | 0.885 | 0.817 | 0.842 | 0.879 |
Specificity | 96.7% | 90.2% | 94.6% | 98.8% | 88.9% | 88.9% | 97.7% | 91.3% | 91.3% | |
Sensitivity | 28.6% | 61.2% | 68.7% | 33.0% | 65.2% | 73.9% | 30.5% | 62.2% | 72.5% | |
BCLC(C) vs. healthy + cirrhotic | AUC | 0.878 | 0.924 | 0.962 | 0.915 | 0.898 | 0.959 | 0.899 | 0.909 | 0.959 |
Specificity | 98.7% | 92.5% | 93.4% | 99.6% | 96.6% | 96.6% | 99.1% | 95.0% | 94.3% | |
Sensitivity | 42.9% | 74.3% | 88.6% | 52.1% | 70.8% | 83.3% | 48.2% | 71.1% | 85.5% | |
BCLC (C) vs. healthy | AUC | 0.899 | 0.956 | 0.985 | 0.923 | 0.923 | 0.974 | 0.912 | 0.938 | 0.979 |
Specificity | 100.0% | 92.6% | 93.3% | 100.0% | 93.4% | 94.7% | 100.0% | 93.0% | 93.4% | |
Sensitivity | 42.9% | 82.9% | 94.3% | 52.1% | 77.1% | 87.5% | 48.2% | 79.5% | 90.4% | |
BCLC (C) vs. cirrhotic | AUC | 0.848 | 0.877 | 0.928 | 0.899 | 0.850 | 0.931 | 0.877 | 0.861 | 0.927 |
Specificity | 96.7% | 92.4% | 92.4% | 98.8% | 85.2% | 85.2% | 97.7% | 90.2% | 93.1% | |
Sensitivity | 42.9% | 65.7% | 85.7% | 52.1% | 75.0% | 87.5% | 48.2% | 71.1% | 80.7% | |