Fig. 3

Heatmap of single-cell expression of 57 E3 ligases in hematopoietic tissues. The levels of single-cell expression of 57 E3 ligases in different types of hematopoietic cells from the peripheral blood, bone marrow, and spleen in human adults were abstracted from the Human Cell Landscape (HCL) data. In the heatmap, each row represents a cell type, and each column represents an E3 ligase. The color legend shown on the right was determined by averaging the expression values of all cells within a specific cell type. These E3 ligases were clustered by the hierarchical clustering algorithm, and the resulting dendrogram was shown at the bottom. The 57 E3 ligases presented in the figure were chosen according to the criteria: E3 ligases with an average expression value > 0.5 in at least one cell type. Single cell RNA-sequencing (scRNA-seq) data were from the website: https://figshare.com/articles/HCL_DGE_Data/7235471.