Fig. 4

Signal pathways and metabolic pathways involved in abnormal RBP. HnRNP A1 /A2 is involved in the synthesis of M-type pyruvate kinase (PKM2), thereby enhancing the Warburg effect and let-7a-5p/Stat3/hnRNP-A1/PKM2 forms a cyclically regulated aerobic glycolysis. HuR regulates the PI3K/AKT/NF-κB signaling pathway. RNPC1 promotes the STARD13-mediated ceRNA network, thereby inhibiting the occurrence of EMT. The transcription factor ZEB1 protein can inhibit the mRNA level of epithelial splicing regulator protein 1 (ESRP1), resulting in the upregulation of the alternative spliceosome in the cell surface antigen CD44