Fig. 1

CD47 Structure and binding partners. CD47 is a transmembrane protein with 5 transmembrane domains, short intracytoplasmic C-terminal and N-terminal extracellular immunoglobulin variable (IgV) domain. Schematic diagram showing that CD47 can interact with αvβ3 integrin on the same cell or with SIRPα on the phagocytic cell through its IgV domain and activates “don’t eat me” signal. CD47 can also bind thrombospondin-1 (TSP) in the N-terminal, which promotes an interaction between CD47 and αvβ3 integrin and triggers αvβ3 integrin signaling