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Table 3 Clinical parameters, treatments, and outcomes of patients hospitalized due to COVID-19 at Mount Sinai Hospital

From: A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward

Subset of patients treated at Mount Sinai hospital for which full clinical data was available Hospitalized patients total Hospitalized patients alive Hospitalized patients deceased
n = 23 n = 16 n = 7
Clinical presentation
 Fever 70% (16) 69% (11) 71% (5)
 Systolic BP < 90 mmHg 9% (2) 0% (0) 29% (2)
 MAP < 65 mmHg 9% (2) 0% (0) 29% (2)
 Heart rate > 100 bpm 48% (11) 56% (9) 29% (2)
 RR > 20/min 26% (6) 19% (3) 43% (3)
 Oxygen requirement at presentation
  None 57% (13) 69% (11) 29% (2)
  Nasal cannula or NRB mask 30% (7) 25% (4) 43% (3)
  High-flow oxygen, CPAP, or BiPAP 4% (1) 0% (0) 14% (1)
  Mechanical ventilation 9% (2) 6% (1) 14% (1)
Treatment initiated
 Remdesivir 4% (1) 6% (1) 0% (0)
 Hydroxychloroquine 74% (17) 69% (11) 86% (6)
 Azithromycin 74% (17) 75% (12) 71% (5)
 Other antibiotics 83% (19) 81% (13) 86% (6)
 G-CSF 26% (6) 38% (6) 0% (0)
 Therapeutic anticoagulation 78% (18) 69% (11) 100% (7)
 Systemic corticosteroids 43% (10) 31% (5) 71% (5)
 Anti-TNF 4% (1) 0% (0) 14% (1)
 Anti-IL-1 9% (2) 0% (0) 29% (2)
 Anti-IL-6 17% (4) 13% (2) 29% (2)
 Selinexor 22% (5) 25% (4) 14% (1)
 Convalescent plasma 4% (1) 6% (1) 0% (0)
Complications
 Highest level of oxygen requirement
  None 26% (6) 31% (5) 14% (1)
  Nasal cannula or NRB mask 39% (9) 56% (9) 0% (0)
  High-flow oxygen, CPAP, or BiPAP 13% (3) 6% (1) 29% (2)
  Mechanical ventilation 22% (5) 6% (1) 57% (4)
 ICU 30% (7) 6% (1) 86% (6)
 Acute kidney injury 52% (12) 38% (6) 86% (6)
 Shock 30% (7) 0% (0) 100% (7)
 Sepsis or HAP/VAP 9% (2) 6% (1) 14% (1)
 C. difficile infection 4% (1) 6% (1) 0% (0)
 Cardiac complication 30% (7) 19% (3) 57% (4)
Worst biochemical parameters
 CRP 151.5 [178.1] 144.9 [107.7] 294.1 [132.9]
 Total leukocyte count (× 10e9/L) (lowest) 3.3 [2.6] 2.9 [2.4] 4.3 [8.4]
 Absolute lymphocyte count (× 10e9/L) (lowest) 0.3 [0.4] 0.4 [0.5] 0.2 [0.2]
 Creatinine (mg/dL) 1.6 [2.4] 1.1 [1.4] 2.7 [2]
 Procalcitonin (ng/mL) 0.8 [2.1] 0.5 [0.8] 2.7 [9.9]
 Ferritin (μg/L) 2537 [2578] 1282 [2170.5] 3409 [2018]
 Fibrinogen (mg/dL) 667 [167] 646 [209.5] 673.5 [43.8]
 D-dimer (mg/L) 2.5 [14.3] 2 [2.6] 20 [7.6]
 LDH (U/L) 531.5 [515.8] 478 [329] 739 [344]
 ALT (U/L) 61 [58.5] 43.5 [52.8] 79 [32]
 AST (U/L) 78 [62.5] 49.5 [54.3] 101 [51.5]
 IL-1β (pg/mL) 0.5 [0.9] 0.5 [0.8] 0.5 [0.9]
 IL-6 (pg/mL) 128.5 [211.6] 119.3 [102.4] 296.8 [821.2]
 IL-8 (pg/mL) 65.4 [62.3] 46.6 [67.6] 137 [89.6]
 TNF-alfa (pg/mL) 28.7 [11] 29.4 [8.4] 21.3 [15.2]
  1. Note: values are presented as percentage (n) or median [interquartile range]
  2. Abbreviations: BP blood pressure, MAP mean arterial pressure, SpO2 oxygen saturation, RR respiratory rate, NRB non-rebreather, CPAP continuous positive airway pressure, BiPAP bi-level positive airway pressure, G-CSF granulocyte colony stimulating factor, TNF tumor necrosis factor, IL interleukin, ICU intensive care unit, HAP hospital-acquired pneumonia, VAP ventilator-associated pneumonia, CRP C-reactive protein, LDH lactate dehydrogenase, ALT alanine aminotransferase, AST aspartate aminotransferase