|
Clinical presentation
|
|
Fever
|
70%
|
(16)
|
69%
|
(11)
|
71%
|
(5)
|
|
Systolic BP < 90 mmHg
|
9%
|
(2)
|
0%
|
(0)
|
29%
|
(2)
|
|
MAP < 65 mmHg
|
9%
|
(2)
|
0%
|
(0)
|
29%
|
(2)
|
|
Heart rate > 100 bpm
|
48%
|
(11)
|
56%
|
(9)
|
29%
|
(2)
|
|
RR > 20/min
|
26%
|
(6)
|
19%
|
(3)
|
43%
|
(3)
|
|
Oxygen requirement at presentation
|
|
None
|
57%
|
(13)
|
69%
|
(11)
|
29%
|
(2)
|
|
Nasal cannula or NRB mask
|
30%
|
(7)
|
25%
|
(4)
|
43%
|
(3)
|
|
High-flow oxygen, CPAP, or BiPAP
|
4%
|
(1)
|
0%
|
(0)
|
14%
|
(1)
|
|
Mechanical ventilation
|
9%
|
(2)
|
6%
|
(1)
|
14%
|
(1)
|
|
Treatment initiated
|
|
Remdesivir
|
4%
|
(1)
|
6%
|
(1)
|
0%
|
(0)
|
|
Hydroxychloroquine
|
74%
|
(17)
|
69%
|
(11)
|
86%
|
(6)
|
|
Azithromycin
|
74%
|
(17)
|
75%
|
(12)
|
71%
|
(5)
|
|
Other antibiotics
|
83%
|
(19)
|
81%
|
(13)
|
86%
|
(6)
|
|
G-CSF
|
26%
|
(6)
|
38%
|
(6)
|
0%
|
(0)
|
|
Therapeutic anticoagulation
|
78%
|
(18)
|
69%
|
(11)
|
100%
|
(7)
|
|
Systemic corticosteroids
|
43%
|
(10)
|
31%
|
(5)
|
71%
|
(5)
|
|
Anti-TNF
|
4%
|
(1)
|
0%
|
(0)
|
14%
|
(1)
|
|
Anti-IL-1
|
9%
|
(2)
|
0%
|
(0)
|
29%
|
(2)
|
|
Anti-IL-6
|
17%
|
(4)
|
13%
|
(2)
|
29%
|
(2)
|
|
Selinexor
|
22%
|
(5)
|
25%
|
(4)
|
14%
|
(1)
|
|
Convalescent plasma
|
4%
|
(1)
|
6%
|
(1)
|
0%
|
(0)
|
|
Complications
|
|
Highest level of oxygen requirement
|
|
None
|
26%
|
(6)
|
31%
|
(5)
|
14%
|
(1)
|
|
Nasal cannula or NRB mask
|
39%
|
(9)
|
56%
|
(9)
|
0%
|
(0)
|
|
High-flow oxygen, CPAP, or BiPAP
|
13%
|
(3)
|
6%
|
(1)
|
29%
|
(2)
|
|
Mechanical ventilation
|
22%
|
(5)
|
6%
|
(1)
|
57%
|
(4)
|
|
ICU
|
30%
|
(7)
|
6%
|
(1)
|
86%
|
(6)
|
|
Acute kidney injury
|
52%
|
(12)
|
38%
|
(6)
|
86%
|
(6)
|
|
Shock
|
30%
|
(7)
|
0%
|
(0)
|
100%
|
(7)
|
|
Sepsis or HAP/VAP
|
9%
|
(2)
|
6%
|
(1)
|
14%
|
(1)
|
|
C. difficile infection
|
4%
|
(1)
|
6%
|
(1)
|
0%
|
(0)
|
|
Cardiac complication
|
30%
|
(7)
|
19%
|
(3)
|
57%
|
(4)
|
|
Worst biochemical parameters
|
|
CRP
|
151.5
|
[178.1]
|
144.9
|
[107.7]
|
294.1
|
[132.9]
|
|
Total leukocyte count (× 10e9/L) (lowest)
|
3.3
|
[2.6]
|
2.9
|
[2.4]
|
4.3
|
[8.4]
|
|
Absolute lymphocyte count (× 10e9/L) (lowest)
|
0.3
|
[0.4]
|
0.4
|
[0.5]
|
0.2
|
[0.2]
|
|
Creatinine (mg/dL)
|
1.6
|
[2.4]
|
1.1
|
[1.4]
|
2.7
|
[2]
|
|
Procalcitonin (ng/mL)
|
0.8
|
[2.1]
|
0.5
|
[0.8]
|
2.7
|
[9.9]
|
|
Ferritin (μg/L)
|
2537
|
[2578]
|
1282
|
[2170.5]
|
3409
|
[2018]
|
|
Fibrinogen (mg/dL)
|
667
|
[167]
|
646
|
[209.5]
|
673.5
|
[43.8]
|
|
D-dimer (mg/L)
|
2.5
|
[14.3]
|
2
|
[2.6]
|
20
|
[7.6]
|
|
LDH (U/L)
|
531.5
|
[515.8]
|
478
|
[329]
|
739
|
[344]
|
|
ALT (U/L)
|
61
|
[58.5]
|
43.5
|
[52.8]
|
79
|
[32]
|
|
AST (U/L)
|
78
|
[62.5]
|
49.5
|
[54.3]
|
101
|
[51.5]
|
|
IL-1β (pg/mL)
|
0.5
|
[0.9]
|
0.5
|
[0.8]
|
0.5
|
[0.9]
|
|
IL-6 (pg/mL)
|
128.5
|
[211.6]
|
119.3
|
[102.4]
|
296.8
|
[821.2]
|
|
IL-8 (pg/mL)
|
65.4
|
[62.3]
|
46.6
|
[67.6]
|
137
|
[89.6]
|
|
TNF-alfa (pg/mL)
|
28.7
|
[11]
|
29.4
|
[8.4]
|
21.3
|
[15.2]
|
