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Table 1 DC classification

From: Dendritic cell biology and its role in tumor immunotherapy

DC subtype

Identification basis

Presence in vivo

Main surface markers

Secreted molecules

Function

Mouse

Human

pDCs

120G8+, B220+, CD11c+, LY6C+, CD11b–

Circulate through the blood and lymphoid tissues

TLR7, TLR9, TLR12, RLR, STING, CLEC12A

TLR7, TLR9, RLR, STING, CLEC12A

CD317, SIGLECH, B220, BDC2*, BDC4*

(1) Type I interferons, (2) antigen presentation, (3) T cell priming

cDC1s

cDC1s (XCR1hiCD172low)

Thymus, spleen and lymph nodes

TLR2-, TLR4, TLR11–TLR13, STING, CLEC12A

TLR1, TLR3, TLR6, TLR8, TLR10, STING, CLEC12A

XCR1, CLEC9A, (CD103), (CD8α), BDCA3*

Cross-priming

cDC2s

cDC2s (XCR1lowCD172hi)

Thymus, spleen and lymph nodes

TLR1, TLR2, TLR4–TLR9, TLR13, RLR, NLR, STING, CLEC4A, CLEC6A, CLEC7A, (CLEC12A)

TLR1–TLR9, RLR, NLR, STING, LEC4A, CLEC6A, CLEC7A, CLEC10A, CLEC12A

CD11b, SIRPa, (CD4), (DCIR2)

CD4+ T cell priming

MoDCs

CD11c+, Ly6C+, CD103

Differentiate from monocytes in peripheral tissues on inflammation. Resident in skin, lung, and intestine

CD11c+, MHC-II+, CD11b+, Ly6C+, CD64+, CD206+, CD209+, CD14+, CCR2+

CD11c+, MHC-II+, CD11b+, Ly6C+, CD64+, CD206+, CD209+, CD14+, CCR2+, CD103+

CD11b, CCR2, LY6C, CD115

Inflammation