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Table 1 DC classification

From: Dendritic cell biology and its role in tumor immunotherapy

DC subtype Identification basis Presence in vivo Main surface markers Secreted molecules Function
Mouse Human
pDCs 120G8+, B220+, CD11c+, LY6C+, CD11b– Circulate through the blood and lymphoid tissues TLR7, TLR9, TLR12, RLR, STING, CLEC12A TLR7, TLR9, RLR, STING, CLEC12A CD317, SIGLECH, B220, BDC2*, BDC4* (1) Type I interferons, (2) antigen presentation, (3) T cell priming
cDC1s cDC1s (XCR1hiCD172low) Thymus, spleen and lymph nodes TLR2-, TLR4, TLR11–TLR13, STING, CLEC12A TLR1, TLR3, TLR6, TLR8, TLR10, STING, CLEC12A XCR1, CLEC9A, (CD103), (CD8α), BDCA3* Cross-priming
cDC2s cDC2s (XCR1lowCD172hi) Thymus, spleen and lymph nodes TLR1, TLR2, TLR4–TLR9, TLR13, RLR, NLR, STING, CLEC4A, CLEC6A, CLEC7A, (CLEC12A) TLR1–TLR9, RLR, NLR, STING, LEC4A, CLEC6A, CLEC7A, CLEC10A, CLEC12A CD11b, SIRPa, (CD4), (DCIR2) CD4+ T cell priming
MoDCs CD11c+, Ly6C+, CD103 Differentiate from monocytes in peripheral tissues on inflammation. Resident in skin, lung, and intestine CD11c+, MHC-II+, CD11b+, Ly6C+, CD64+, CD206+, CD209+, CD14+, CCR2+ CD11c+, MHC-II+, CD11b+, Ly6C+, CD64+, CD206+, CD209+, CD14+, CCR2+, CD103+ CD11b, CCR2, LY6C, CD115 Inflammation