From: Dendritic cell biology and its role in tumor immunotherapy
DC subtype | Identification basis | Presence in vivo | Main surface markers | Secreted molecules | Function | |
---|---|---|---|---|---|---|
Mouse | Human | |||||
pDCs | 120G8+, B220+, CD11c+, LY6C+, CD11b– | Circulate through the blood and lymphoid tissues | TLR7, TLR9, TLR12, RLR, STING, CLEC12A | TLR7, TLR9, RLR, STING, CLEC12A | CD317, SIGLECH, B220, BDC2*, BDC4* | (1) Type I interferons, (2) antigen presentation, (3) T cell priming |
cDC1s | cDC1s (XCR1hiCD172low) | Thymus, spleen and lymph nodes | TLR2-, TLR4, TLR11–TLR13, STING, CLEC12A | TLR1, TLR3, TLR6, TLR8, TLR10, STING, CLEC12A | XCR1, CLEC9A, (CD103), (CD8α), BDCA3* | Cross-priming |
cDC2s | cDC2s (XCR1lowCD172hi) | Thymus, spleen and lymph nodes | TLR1, TLR2, TLR4–TLR9, TLR13, RLR, NLR, STING, CLEC4A, CLEC6A, CLEC7A, (CLEC12A) | TLR1–TLR9, RLR, NLR, STING, LEC4A, CLEC6A, CLEC7A, CLEC10A, CLEC12A | CD11b, SIRPa, (CD4), (DCIR2) | CD4+ T cell priming |
MoDCs | CD11c+, Ly6C+, CD103 | Differentiate from monocytes in peripheral tissues on inflammation. Resident in skin, lung, and intestine | CD11c+, MHC-II+, CD11b+, Ly6C+, CD64+, CD206+, CD209+, CD14+, CCR2+ | CD11c+, MHC-II+, CD11b+, Ly6C+, CD64+, CD206+, CD209+, CD14+, CCR2+, CD103+ | CD11b, CCR2, LY6C, CD115 | Inflammation |