Skip to main content

Table 2 Fc receptor classification and function

From: Dendritic cell biology and its role in tumor immunotherapy

FcR

Type

Affinity of binding IgG

Function domain

Fc signal

Fc expression cells

Short-term effects

Long-term effects

Constitutive

Inducible

FcR I

I

High

Fc domains within IgG

ITAM

Monocytes

Neutrophils, eosinophils, dendritic cells

FcrRIIa

I

Low

Fc domains within IgG

ITAM

Monocytes, neutrophils, eosinophils, macrophages, dendritic cells, platelets, granulocytes

Degranulation, ROI production, phagocytosis, cytokine, chemokine expression, platelet activation

Proinflammatory molecule stimulation and release, cell survival, motility, platelet binding to leukocytes, enhanced antigen process, presentation, T cell responses

FcrRIIb

I

Low

Fc domains within IgG

ITIM

B cells, monocytes, neutrophils, eosinophils, macrophages, dendritic cells, plasma cells

B cell selection

High-affinity IgG responses

FcrRIIIa

I

Low

Fc domains within IgG

ITAM

NK cells

Dendritic cells

Phagocytosis, cytokine and chemokine expression, cell activation, degranulation

Monocyte recruitment, differentiation, proinflammatory pathway stimulate, cytotoxicity, cell survival, effector leukocyte impact, immune complexes generation

FcrRIIIb

I

Low

Fc domains within IgG

ITAM

Granulocytes

Neutrophils

Degranulation, ROI production, phagocytosis

Proinflammatory molecule release, cell survival, motility, myeloid leukocyte impact

DC-SIGN

II

Sialylated Fc glycoforms

   

Phagocytosis, cytokine and chemokine expression

Macrophage polarization, IgG-mediated inflammation

DC23

II

Sialylated Fc glycoforms

 

B cells

T cells, monocytes, neutrophils, eosinophils

B cell selection

Constitutive high-affinity IgG responses

  1. Note: High-affinity FcγR, capable of binding monomeric IgG; low-affinity FcγR, variable affinities by subclasses