Table 2 Fc receptor classification and function
From: Dendritic cell biology and its role in tumor immunotherapy
FcR | Type | Affinity of binding IgG | Function domain | Fc signal | Fc expression cells | Short-term effects | Long-term effects | |
|---|---|---|---|---|---|---|---|---|
Constitutive | Inducible | |||||||
FcR I | I | High | Fc domains within IgG | ITAM | Monocytes | Neutrophils, eosinophils, dendritic cells | — | — |
FcrRIIa | I | Low | Fc domains within IgG | ITAM | Monocytes, neutrophils, eosinophils, macrophages, dendritic cells, platelets, granulocytes | — | Degranulation, ROI production, phagocytosis, cytokine, chemokine expression, platelet activation | Proinflammatory molecule stimulation and release, cell survival, motility, platelet binding to leukocytes, enhanced antigen process, presentation, T cell responses |
FcrRIIb | I | Low | Fc domains within IgG | ITIM | B cells, monocytes, neutrophils, eosinophils, macrophages, dendritic cells, plasma cells | — | B cell selection | High-affinity IgG responses |
FcrRIIIa | I | Low | Fc domains within IgG | ITAM | NK cells | Dendritic cells | Phagocytosis, cytokine and chemokine expression, cell activation, degranulation | Monocyte recruitment, differentiation, proinflammatory pathway stimulate, cytotoxicity, cell survival, effector leukocyte impact, immune complexes generation |
FcrRIIIb | I | Low | Fc domains within IgG | ITAM | Granulocytes | Neutrophils | Degranulation, ROI production, phagocytosis | Proinflammatory molecule release, cell survival, motility, myeloid leukocyte impact |
DC-SIGN | II | — | Sialylated Fc glycoforms |  |  |  | Phagocytosis, cytokine and chemokine expression | Macrophage polarization, IgG-mediated inflammation |
DC23 | II | — | Sialylated Fc glycoforms |  | B cells | T cells, monocytes, neutrophils, eosinophils | B cell selection | Constitutive high-affinity IgG responses |