Table 1 The classification of extrachromosomal circular DNA in cancer
Name | Size range | Replication | Function |
|---|---|---|---|
SpcDNA | Several hundred bp | Self-replicate | Contributing to telomere homeostasis |
T-circles/c-circles | 0.3 to 30 Kb | Self-replicate | Serving as templates for telomere elongation |
MicroDNA | 100 to 400 bp | Self-replicate | Regulating microRNAs |
ERCs | 19.3 to 40.4 Kb | Self-replicate | Serving as templates for ribosomal RNA transcription |
DMs | A few to several Mb | Self-replicate | Leading to oncogene amplification and overexpression |