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Table 1 The classification of extrachromosomal circular DNA in cancer

From: Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

Name Size range Replication Function
SpcDNA Several hundred bp Self-replicate Contributing to telomere homeostasis
T-circles/c-circles 0.3 to 30 Kb Self-replicate Serving as templates for telomere elongation
MicroDNA 100 to 400 bp Self-replicate Regulating microRNAs
ERCs 19.3 to 40.4 Kb Self-replicate Serving as templates for ribosomal RNA transcription
DMs A few to several Mb Self-replicate Leading to oncogene amplification and overexpression