Fig. 2
From: The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing
a T-distributed stochastic neighbor embedding (t-SNE) plot in the expression space of several cancer datasets, plotting the results of the two principal dimensions. The data were obtained from the GDC-PAN cancer data Portal. The PMDS samples do not cluster near other tumor types, AML in particular (black arrowhead), showing a distinct profile. b Boxplot: ddPCR analysis of twelve genes, comparing expression levels between controls and PMDS patients. For each gene, box–whisker plots of concentration values are shown. Genes are classified as upregulated (red), downregulated (blue) and reference (grey). Significant changes in cDNA concentration between control and patients are highlighted (one-tailed t test, corrected for unequal variances *p < 0.05, **p < 0.01, ***p < 0.001)