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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

Fig. 1

The clinical correlation of GSDME in IBD patients. a IHC analyses of GSDME protein in the colonic mucosa from healthy controls (n = 40), UC patients (n = 42) and CD patients (n = 43). b UM un-inflamed mucosa, IM inflamed mucosa. Relative GSDME-NT levels (GSDME-NT/GAPDH) in the inflamed and un-inflamed colonic mucosa from UC patients (n = 15) and CD patients (n = 15) were further compared as determined by the paired t tests. c Representative immunoblot images of the colonic mucosa from UC and CD patients. The full length of GSDME (GSDME-FL) is shown in 56 kDa and GSDME-NT in 37 kDa. d Representative IHC images of the colonic mucosa from healthy controls, UC and CD patients. Scale bars: 400 μm. Yellow asterisks: epithelial cells. Yellow arrows: lymphocytes. NS, not significant; ***P < 0.001

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Journal of Hematology & Oncology

ISSN: 1756-8722

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