Table 3 MicroRNAs in cancer-associated fibroblasts as biomarkers for cancer prognosis
Cancer type | No. of samples | ncRNA | Dysregulation or exomosal | Method | Expression* | Result in | References |
|---|---|---|---|---|---|---|---|
Colorectal cancer | 170 | miR-21 | Dysregulation | ISH | ↓ | Poorer OS | [166] |
Gastric cancer | 120 | miR-106b | Dysregulation | ISH | ↑ | Poorer OS | [208] |
Gastric cancer | 68 | miR-143 | Dysregulation | ISH and qRT-PCR | ↑ | Higher CSM | [209] |
Gastric cancer | 71 | miR-145 | Dysregulation | qRT-PCR | ↑ | Higher CSM | [210] |
Head and neck cancer | 74 | miR-196a | Exomosal | qRT-PCR | ↑ | Poorer OS | [157] |
Hepatocellular carcinoma | 85 | miR-21 | Exomosal | qRT-PCR | ↑ | Poorer OS | [96] |
Lung cancer | 89 | miR-21 | Dysregulation | ISH | ↑ | Poorer OS | [167] |
Lung cancer | 134 | miR-200a | Dysregulation | ISH | ↓ | Poorer OS | [211] |
Pancreatic cancer | 153 | miR-21 | Dysregulation | ISH | ↑ | Poorer OS | [168] |
Oral squamous cell carcinoma | 140 | lncRNA FLJ22447 | Dysregulation | qRT-PCR | ↑ | Poorer OS | [188] |
Ovarian cancer | 62 | 10 lncRNAs | Dysregulation | – | – | Poorer OS | [199] |