Fig. 1
From: Natural killer cell-based immunotherapy for acute myeloid leukemia
Mechanisms of immune escape from NK cell-mediated recognition in AML. Dysfunctional NK cells exhibit an imbalanced receptor expression with the overexpression of inhibitory receptors and the underexpression of activating receptors. AML cells display a defective expression of cognate ligands for NK cell activating and inhibitory receptors. The tumor microenvironment consisting of Treg cells and MDSCs can interfere with the function of NK cells through the secreting of cytokines. MDSC myeloid-derived suppressor cell, NK natural killer cell; Treg regulatory T cell