Fig. 2
From: Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer
ER stress regulates miRNAs and lncRNAs expression. a Sustained IRE1α RNase resulted in rapid degradation of miR-17, miR-34a, miR-96, and miR-125b. PERK-induced miR-211 inhibits CHOP, Bmal1, and Clock in tumor cells. PERK promotes translocation of NF-κB into the nucleus to control the expression of miR-30c-2* under ER stress. miR-30c-2* in turn negatively regulates the expression of XBP1s mRNA. b Activated IRE1 and PERK signaling pathways increase the MALAT1 expression. The transcription factor CHOP transcriptionally regulates expression of lnc-MGC and GOLGA2P10