Fig. 1
From: MCL-1 inhibitors, fast-lane development of a new class of anti-cancer agents
Dependencies of tumor cell lines on MCL-1. Depmap analysis indicated that knockout of MCL-1 using CRISPR/Cas9 could significantly suppress the growth of both solid and blood cancers, the latter being more affected. Lower values indicate that a gene is more likely to be dependent in a given cell line. A score of 0 indicates non-essential genes whereas a score of -1 corresponds to the median of all common essential genes. Suppression of BCL-2 affected the survival of hematological tumor cell lines to a lesser extent, but had no effect on solid tumor cells (www.depmap.org)