Table 2 Summary of CAR T cell results in diffuse large B cell lymphoma

CD19

Axicabtagene ciloleucel

ZUMA-1 (NCT02348216)

1/2

101

2.0 × 10⁶ CAR T cells/kg

83

58

[13]

CD19

axicabtagene ciloleucel (in combination with atezolizumab)

ZUMA-6 (NCT02926833)

1

12

2.0 × 10⁶ CAR T cells/kg

90

60

[22]

CD19

tisagenlecleucel

JULIET (NCT02445248)

2

93

0.1–6 × 10⁸ CAR T cells

52

40

[12]

CD19

lisocabtagene maraleucel

TRANSCEND NHL 001 (NCT02631044)

1

268

50–150 × 10⁶ CAR T cells

73

53

[139]

CD19

CTL019

NCT02030834

2a

28

1.79–5.00 × 10⁶ CAR T cells

64

43

[11]

CD19

ET019003

NCT04014894

1

6

2–3 × 10⁶ CAR T cells/kg

100

–

[140]

CD19

FMC63-28Z

NCT00924326

1/2

7

1–5 × 10⁶ CAR T cells/kg

85

71

[141]

CD19/CD22

AUTO3 (in combination with pembrolizumab)

ALEXANDER (NCT03287817)

1/2

24

50 × 10⁶ CAR T cells

57

29

[21]