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Table 2 In vitro sensitivities (EC50, pM) to target antigen-specific bispecific antibodies in osteosarcoma cell lines

From: GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma

  GD2 HER2 B7H3 CSPG4 L1CAM Lewis Y
Osteosarcoma
 143B 0.2 10 130 454 329 1440
 U-2 OS 0.5 11 150 116 92 692
 MG-63 0.4 8 109 558 397 4655
 HOS 3906 10 274 645 158 312
 Saos-2  > 5000 18 120 500 229 468
Osteoblast
 hFOB 1.19  > 5000 69 126 498 121 600