Table 2 In vitro sensitivities (EC50, pM) to target antigen-specific bispecific antibodies in osteosarcoma cell lines
From: GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma
| Â | GD2 | HER2 | B7H3 | CSPG4 | L1CAM | Lewis Y |
|---|---|---|---|---|---|---|
Osteosarcoma | ||||||
 143B | 0.2 | 10 | 130 | 454 | 329 | 1440 |
 U-2 OS | 0.5 | 11 | 150 | 116 | 92 | 692 |
 MG-63 | 0.4 | 8 | 109 | 558 | 397 | 4655 |
 HOS | 3906 | 10 | 274 | 645 | 158 | 312 |
 Saos-2 |  > 5000 | 18 | 120 | 500 | 229 | 468 |
Osteoblast | ||||||
 hFOB 1.19 |  > 5000 | 69 | 126 | 498 | 121 | 600 |