From: Targeting hypoxic tumor microenvironment in pancreatic cancer
ncRNAs | Expression in PC | Mechanisms | Main functions | References |
---|---|---|---|---|
lncRNA | ||||
NORAD | Up | NORAD—miR-125a-3p—RhoA | Promotes EMT and metastasis | [165] |
FEZF1-AS1 | Up | FEZF1-AS1—miR-142—HIF-1α | Promotes cell proliferation and invasion ability | [167] |
MTA2TR | Up | MTA2TR—ATF3—MTA2—HIF-1α loop | Promotes cell proliferation and invasion | [174] |
BX111 | Up | HIF-1α—YB1—ZEB1—E-cadherin, MMP2 | Promotes growth and metastasis | [175] |
NUTF2P3-001 | Up | NUTF2P3-001—miR-3923—KRAS | Promotes the proliferation and invasion | [176] |
CF129 | Down | HIF-1α—CF129—p53—FOXC2 loop | Inhibits cell proliferation, invasion, and metastasis | [177] |
miRNA | ||||
circ_0000977 | Up | circ_0000977—miR-153—HIF-1α, ADAM10 | Promotes immune escape | [178] |
miR-191 | Up | HIF-1α—miR-191 | Promotes tumorigenesis | [179] |
miR-21 | Up | miR-21—HIF-1α—VEGF, MMP2, MMP9 | Promotes cell proliferation, migration, and invasion | [180] |
HIF-1α—miR-21 | Avoids apoptosis | [181] | ||
miR-210 | Up | miR-210—HOXA9—NF-κB | Promotes EMT | [132] |
miR-212 | Up | HIF-1α—miR-212 | Promotes progression | [182] |
miR-224 | Up | miR-224—TXNIP—HIF-1α | Promotes cell proliferation and migration | [168] |
miR-301a | Up | HIF-2α—miR-301a—TP63 | Promotes EMT | [166] |
miR-301a—TAp63 | [173] | |||
miR-301a-3p | Up | miR-301a-3p—PTEN/PI3K—M2 macrophages polarization | Promotes metastasis | [169] |
miR-646 | Up | HIF-1α—miR-646—MIIP—HDAC6 loop | Promotes proliferation and invasion | [183] |
miR-124 | Down | miR-124—MCT1—HIF-1α—LDHA | Increases intracellular pH, inhibits glycolytic activity and tumor growth | [53] |
miR-125a | Down | miR-125a—Mfn2—mitochondrial fission | Impairs cell migration capacity | [170] |
miR-138-5p | Down | miR-138-5p—SIRT1—FOXO1—Rab7 | Inhibits autophagy and tumor growth | [104] |
miR-142 | Down | miR-142—HIF-1α—vimentin, VEGF-C, E-cadherin | Inhibits proliferation, EMT, and invasion | [184] |
miR-150 | Down | miRNA-150—CXCR4 | Inhibits migration and invasion | [185] |
miR-519 | Down | miR-519—PD-L1 | Inhibits cell invasiveness, and induces apoptosis | [186] |
miR-548an | Down | HIF-1α—HDAC1—miR-548an—vimentin | Inhibits the proliferation and invasion | [187] |