Fig. 2
From: FGFR-TKI resistance in cancer: current status and perspectives
Mechanisms of lysosome-mediated FGFR-TKI sequestration. Firstly, lipophilic weakly basic TKIs are trapped in the lysosome cavity by free diffusion and protonation. Secondly, TKIs are pumped into lysosome by ABC transporters. Thirdly, under stimulation of mTORC1 inactivation and TKI-induced Ca2+ release, the transcription factor TFEB translocates into the nucleus and mediates lysosome biosynthesis, enhancing TKI sequestration