Fig. 1

RUNX1 and CBFA2T3 mRNA level are positively correlated in ETV6-RUNX1 BCP-ALL. a and b The graphs represent the mRNA expression level of CBFA2T3 and RUNX1 in human pediatric ETV6-RUNX1 BCP-ALL bone marrow mononuclear cells and the other non-ETV6-RUNX1 BCP-ALL bone marrow mononuclear cells. Data of mRNA levels (expressed in Fragments Per Kilobase Million—FPKM) have been extracted from the St. Jude Children's Research Hospital RNA-Seq Pediatric Cancer Data Portal [31]. For a ****p < 0.0001 in t-test between both conditions, for b a Pearson correlation has been performed. ns, non significant. Mean data and numbers of samples (n) are indicated above each graph. c Correlation between RUNX1 and CBFA2T3 mRNA levels originating from REH cells and Nalm6 cells that overexpress or are depleted for RUNX1 or CBFA2T3. Statistical analysis has been performed using Pearson correlation. n, number of samples per condition