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Fig. 10 | Journal of Hematology & Oncology

Fig. 10

From: Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

Fig. 10

X-ray structure of AFF4 CHD homodimer (PDB: 6R80) and AFF4 in complex with ELL2 (PDB: 5JW9). a Overview of AFF4 CHD homodimer. b A close-up view of the dimer interface. The AFF4 CHD homodimer is presented as cartoon models with one monomer in cyan and the other in orange. c Overview of the AFF4-ELL2 complex. d A close-up view of the AFF4-ELL2 interaction. The AFF4-ELL2 complex is presented as cartoon models with AFF4 in yellow and ELL2 in cyan. Hydrogen bonds are shown as yellow dashed lines

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Journal of Hematology & Oncology

ISSN: 1756-8722

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