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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

Fig. 6

NMR structure of KIX-c-Myb-MLL1 ternary complex (PDB: 2AGH) and compounds inhibiting the MLL1-CBP interaction. a Overview of MLL1 peptide binding to KIX-c-Myb complex. MLL1 is shown as sticks with C atom in yellow. KIX and c-Myb are shown as surfaces in cyan and magenta, respectively. b A close-up view of the interactions between MLL1 and KIX-c-Myb complex. c compounds inhibiting the MLL1-CBP interaction

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