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Table 3 Binding affinity (Kd), structure, and inhibitors of the critical PPIs involving MLL1 fusion proteins

From: Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

PPIs Kd (μM) Structures (PDB) Inhibitors
AFF4-ELL2 0.086 [190] 5JW9 [190] None
AFF4-Cyclin T1 0.1 [191] 4IMY [191] [192]
AFF4-P-TEFb 0.01 [191] 4IMY [191] [192]
AFF4-Tat-P-TEFb 0.0009 [191] 4OR5 [193] None
AF9(AHD)-AF4 0.0002 [194] 2LM0 [194] [195]
AF9(AHD)-DOT1L 0.0016 [194] 2MV7 [196] [197]
ENL(AHD)-DOT1L 0.2 or 1.34 [198] None None
AF9 or ENL AHD-CBX8  > 0.5 or 0.11 [199] 2N4Q [199] None
AF9 or ENL AHD-BCoR 0.018 or 0.002 nM [199] 6B7G [199] None
AF9(YEATS)-H3K9ac 3.7 [172] 4TMP [172] [200,201,202,203,204]
ENL(YEATS)-H3K9ac 32.2 [205] None [200,201,202,203,204]
ENL(YEATS)-H3K27ac 30.5 [205] 5J9S [205] [200,201,202,203,204]