Skip to main content

Table 3 Efficacy of Pralsetinib in ARROW trial

From: Therapeutic strategies in RET gene rearranged non-small cell lung cancer

 

Overall (n = 116)

Prior platinum treatment (n = 80)

No prior systemic treatment (n = 26)

Measurable Brain Metastases (n = 9)

ORR, %

65 (5% CI 55–73)

61 (95% CI 50–72)

73 (95% CI 52–88)

55

DOR

NR

DCR, %

93 (87–97)

95 (95% CI 88–99)

88 (9% CI 70–98)

  1. ORR, Objective Response Rates; DOR, Duration Of Response; DCR, Disease Control Rates. ORR was similar regardless of RET fusion partner, prior therapies, or central nervous system involvement. Overall, there were 7 (6%) completed responses, 4 (5%) in prior platinum patients and 3 (12%) in treatment naïve patients