Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Table 2 Transplant characteristics

Clinical parameter	MSD (n = 1891)	Haplo (n = 413)	p
Conditioning intensity
Myeloablative conditioning, n (%)	1574 (83.2%)	281 (68%)	< 0.0001
Reduced intensity conditioning, n (%)	317 (16.8%)	132 (32%)
TBI
CT	663 (35.1%)	237 (57.4%)	< 0.0001
TBI	1228 (64.9%)	176 (42.6%)
Graft source
Bone marrow	351 (18.6%)	191 (46.2%)	< 0.0001
Peripheral blood	1540 (81.4%)	222 (53.8%)
PTCy
No PTCy	1812 (95.8%)	30 (7.3%)	< 0.0001
PTCy	79 (4.2%)	383 (92.7%)
In vivo T-cell depletion
No ATG	1537 (81.3%)	352 (85.2%)	0.058
ATG	354 (18.7%)	61 (14.8%)

MSD: matched sibling donor, Haplo: haploidentical transplantation, MAC: myeloablative conditioning, RIC: reduced intensity conditioning, TBI: total body irradiation; BM: bone marrow; PB: mobilized peripheral blood stem cells; PTCy: post-transplantation cyclophosphamide; ATG: anti-thymocyte globulin; MAC: myeloablative conditioning; TBI: total body irradiation; CT: chemotherapy; RIC: reduced intensity conditioning

ISSN: 1756-8722