Table 1 Expression and clinical significance of UBE2F and UBE2M in tumors
From: Targeting neddylation E2s: a novel therapeutic strategy in cancer
| Â | Cancer | Expression | Function |
|---|---|---|---|
UBE2M | Osteosarcoma [98] | Overexpressed | Promotes cell viability |
| Â | Overexpressed | Associated with poor prognosis | |
| Â | Lung cancer [87] | Overexpressed | Associated with poor survival |
| Â | Breast cancer [99] | Overexpressed | Worsens prognosis |
| Â | Intrahepatic cholangiocarcinoma [101] | Overexpressed | Associated with prognosis |
| Â | Osteoarthritis [100] | Overexpressed | Promotes apoptosis |
| Â | Esophageal squamous cell carcinoma [88] | Overexpressed | Associated with poor survival |
UBE2F | Non-small cell lung cancer [89] | Overexpressed | Associated with poor survival |