Fig. 3

GSEA shows that 8-Cl-Ado and VEN synergize in inhibition of fatty acid metabolism in AML. Gene set enrichment analysis (GSEA) graphs of genes involved in fatty acid metabolism (Hallmark fatty acid metabolism) upon treatment of MV4-11 AML cells with 10 nM VEN or control (a), 250 nM 8-Cl-Ado plus 10 nM VEN or control (b), for 4 to 24 h. c Fatty acid metabolism GSEA for direct comparison of VEN/8-Cl-Ado versus VEN alone. Cells were treated as described above. N = 2. ES enrichment score, NES normalized enrichment score, FDR false discovery rate