Table 2 The PK profiles of epacadostat (INCB024360)
From: Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy
Species | CL (L/h/kg) | Vss (L/kg) | iv t1/2 (h) | AUC (μM h) | F (%) | t1/2 (h) |
|---|---|---|---|---|---|---|
Rat | 1.1 | 2.0 | 1.4 | 1.3 | 11 | 2.2 |
Dog | 0.5 | 0.7 | 3.1 | 29 | 59 | 4.9 |
Cyno | 0.8 | 1.8 | 3.3 | 9.3 | 33 | 2.7 |