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Table 2 The PK profiles of epacadostat (INCB024360)

From: Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

Species CL (L/h/kg) Vss (L/kg) iv t1/2 (h) AUC (μM h) F (%) t1/2 (h)
Rat 1.1 2.0 1.4 1.3 11 2.2
Dog 0.5 0.7 3.1 29 59 4.9
Cyno 0.8 1.8 3.3 9.3 33 2.7
  1. CL, plasma clearance; Vss, volume distribution stead state; t1/2, half-life; AUC, area under the concentration-time curve; F, Oral bioavailability; iv, intravenous injection; Cyno, cynomologous monkeys