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Table 3 The PK profiles of BMS-986205

From: Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

Species CL (mL/min/kg) Vss (L/kg) t1/2 (h) F (%)
Rat 27 3.8 3.9 4
Dog 25 5.7 4.7 39
Cyno 19 4.1 6.6 10
  1. CL, plasma clearance; Vss, volume distribution stead state; t1/2, half-life; F, oral bioavailability; Cyno, cynomologous monkeys