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Table 1 Baseline demographic and clinical characteristics

From: Subcutaneous envafolimab monotherapy in patients with advanced defective mismatch repair/microsatellite instability high solid tumors

Characteristic

CRC

Non-CRC

Overall study population

(N = 103)

 ≥ 2 Prior therapies (N = 41)

1 Prior therapy (N = 24)

Total

(N = 65)

GC

(N = 18)

Other solid tumors

(N = 20)

Total

(N = 38)

Age (years)

       

Median

48.0

50.5

49.0

61.0

56.0

58.5

53.0

Range

25–77

22–76

22–77

34–72

36–75

34–75

22–77

Sex, n (%)

       

Male

30 (73)

13 (54)

43 (66)

14 (78)

8 (40)

22 (58)

65 (63)

Female

11 (27)

11 (46)

22 (34)

4 (22)

12 (60)

16 (42)

38 (37)

Ethnicity, n (%)

       

Han Chinese

39 (95)

21 (87.5)

60 (92)

18 (100)

20 (100)

38 (100)

98 (95)

Other

2 (5)

3 (12.5)

5 (8)

0

0

0

5 (5)

ECOG PS, n (%)

       

0

10 (24)

7 (29)

17 (26)

3 (17)

7 (35)

10 (26)

27 (26)

1

31 (76)

17 (71)

48 (74)

15 (83)

13 (65)

28 (74)

76 (74)

Cancer diagnosis, n (%)

       

Colorectal cancer

41

24

65

–

–

–

65 (63)

Gastric/gastroesophageal junction cancer

–

–

–

18

–

18

18 (17)

Other solid tumors

–

–

–

–

20

20

20 (19)

Endometrial cancer

–

–

–

–

6

6

6 (6)

Hepatocellular cancer

–

–

–

–

2

2

2 (2)

Hepatocholangiocarcinoma

–

–

–

–

2

2

2 (2)

Bladder cancer

–

–

–

–

1

1

1 (1)

Cervical cancer

–

–

–

–

1

1

1 (1)

Cholangiocarcinoma

–

–

–

–

1

1

1 (1)

Esophageal cancer

–

–

–

–

1

1

1 (1)

Non-small cell lung cancer

–

–

–

–

1

1

1 (1)

Osteosarcoma

–

–

–

–

1

1

1 (1)

Prostate cancer

–

–

–

–

1

1

1 (1)

Renal pelvic carcinoma

–

–

–

–

1

1

1 (1)

Urothelial carcinoma

–

–

–

–

1

1

1 (1)

Uterine sarcoma

–

–

–

–

1

1

1 (1)

Number of prior systemic treatments

       

Median

3

2

3

2

2

2

2

Range

1–7

1–4

1–7

1–4

1–5

1–5

1–7

  1. CRC with ≥ 2 prior therapies included patients previously treated with a fluoropyrimidine-, oxaliplatin-, and irinotecan-containing regimen
  2. CRC with 1 prior therapy included patients previously treated with a fluoropyrimidine- and oxaliplatin- or fluoropyrimidine- and irinotecan-containing regimen
  3. CRC, colorectal cancer; ECOG, Eastern Cooperative Oncology Group; GC, gastric cancer; PS, performance status