Skip to main content

Table 3 Comparison of pretreatment clinical characteristics of older patients with acute myeloid leukemia assigned to the genetic groups

From: A precision medicine classification for treatment of acute myeloid leukemia in older patients

Characteristic CBF
n = 74
NPM1m/ FLT3-ITD‒
n = 107
KMT2A
n = 13
IDH2m
n = 59
IDH1m
n = 35
TP53m
n = 50
Complex
karyotype/TP53wt
n = 28
FLT3m
n = 99
TET2m or WT1m
n = 42
Marker-negative
n = 56
Age, years           
 Median
 Range
66
(60, 78)
68
(60, 84)
69
(60, 77)
71
(60, 86)
71
(60, 85)
70
(60, 84)
69
(61, 78)
70
(60, 89)
71
(62, 85)
69
(60, 86)
Sex, n (%)           
 Male 37 (50) 54 (50) 7 (54) 36 (61) 19 (54) 29 (58) 20 (71) 55 (56) 26 (62) 35 (63)
 Female 37 (50) 53 (50) 6 (46) 23 (39) 16 (46) 21 (42) 8 (29) 44 (44) 16 (38) 21 (38)
Race, n (%)           
 White 61 (86) 98 (92) 11 (85) 55 (95) 31 (91) 42 (86) 23 (85) 90 (94) 38 (90) 51 (93)
 Non-white 10 (14) 8 (8) 2 (15) 3 (5) 3 (9) 7 (14) 4 (15) 6 (6) 4 (10) 4 (7)
Hemoglobin, g/dL           
 Median
 Range
8.8
(4.8, 12.4)
9.4
(5.3, 14.1)
8.5
(5.7, 11.5)
9.3
(5.2, 13.9)
9.4
(6.5, 13.8)
9.2
(6.8, 11.5)
9.4
(6.0, 14.7)
9.5
(4.3, 15.0)
9.1
(3.0, 11.9)
9.1
(6.2, 12.7)
Platelet count, × 109/L           
 Median
 Range
42
(7, 237)
75
(6, 507)
45
(8, 242)
68
(5, 673)
103
(5, 850)
44
(9, 224)
48
(4, 426)
53
(9, 387)
41
(7, 510)
56
(7, 281)
WBC count, × 109/L           
 Median
 Range
15.2
(1.4, 252.0)
29.3
(0.6, 308.5)
41.6
(2.2, 172.9)
13.4
(0.6, 434.1)
11.8
(0.7, 248.0)
7.8
(0.4, 118.0)
18.4
(0.6, 116.1)
52.4
(0.8, 450.0)
23.5
(2.2, 229.5)
14.5
(1.1, 110.0)
% Blood Blasts           
 Median
 Range
40
(0, 96)
40
(0, 97)
71
(1, 99)
46
(0, 97)
55
(0, 99)
27
(0, 88)
34
(0, 94)
69
(0, 97)
57
(0, 99)
33
(0, 86)
% Bone marrow blasts           
 Median
 Range
56
(10, 90)
70
(0, 95)
85
(46, 97)
70
(21, 99)
81
(34, 93)
47
(17, 90)
50
(16, 88)
80
(6, 99)
62
(26, 96)
60
(17, 94)
Extramedullary involvement, n (%) 14 (23) 28 (28) 2 (15) 15 (28) 4 (12) 7 (16) 6 (24) 28 (30) 9 (22) 7 (13)
ELN 2017, n (%)           
 Favorable 74 (100) 107 (100) 0 (0) 6 (11) 2 (6) 1 (2) 1 (4) 22 (23) 4 (11) 4 (8)
 Intermediate 0 (0) 0 (0) 8 (62) 27 (47) 16 (48) 0 (0) 0 (0) 40 (43) 16 (42) 15 (30)
 Adverse 0 (0) 0 (0) 5 (38) 24 (42) 15 (45) 49 (98) 27 (96) 32 (34) 18 (47) 30 (60)
ECOG performance status, n (%)           
 Grade 0 17 (30) 25 (26) 2 (17) 13 (23) 12 (40) 9 (20) 6 (26) 18 (20) 13 (33) 18 (38)
 Grade 1 25 (44) 44 (45) 5 (42) 27 (48) 11 (37) 21 (47) 14 (61) 40 (45) 17 (43) 21 (44)
 Grade 2 11 (19) 26 (27) 4 (33) 11 (20) 6 (20) 9 (20) 3 (13) 25 (28) 7 (18) 8 (17)
 Grade 3 4 (7) 3 (3) 1 (8) 2 (4) 1 (3) 5 (11) 0 (0) 6 (7) 3 (8) 0 (0)
 Grade 4 0 (0) 0 (0) 0 (0) 3 (5) 0 (0) 1 (2) 0 (0) 0 (0) 0 (0) 1 (2)
  1. CBF, core-binding factor; dL, deciliter; ELN, European LeukemiaNet; g, gram; L, liter; m, mutated; n, number; WBC, white blood cell; wt, wild-type