Fig. 4

In vivo sensitivity to NOTCH1-inhibition of a FBXW7 mutated PDX is enhanced by association of imatinib. a Schematic representation of the experiment. b Percentage of hCD45⁺ cells in the blood as assessed by flow cytometry analysis of hCD45-APC after facial vein blood sampling. Evolution is shown on the left; analysis on day 12 is shown on the right. Each dot represents a single animal; mean and standard deviation are shown. Data were analyzed by one-way ANOVA; Bonferroni correction for multiple comparisons testing was applied. c Spleen weight and hCD45 staining results for spleen and bone marrow on day 12. Each dot represents an animal; mean and standard deviation are shown. Data were analyzed by one-way ANOVA, and Bonferroni correction for multiple comparisons testing was applied. ns = not significant (p > 0.05), *p < 0.05, **p < 0.01, ****p < 0.0001