Fig. 3
From: T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors
Schematic view of TCR and CAR structures. a TCR and CD3 molecules form a non-covalent TCR/CD3 receptor complex on the T-cell surface that recognizes and binds to an antigen peptide presented by MHC. b Transgenic CAR expressed on the surface of the T-cell recognizes a protein target (surface antigen) on the tumor cell c. A bispecific antibody (e.g., CD3 antigen bispecific protein) can bind to different antigens presented by MHC and/or d. A protein target on the surface of the tumor cell can be recognized by the TCR/CD3 complex