Fig. 1
From: N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
Schematic illustration of the reported m6A methyltransferase complex (MTC) of human RNAs. a Most of the mRNAs are methylated by the METTL3-METTL14 complex. This complex is composed of other adaptor proteins, including WTAP, VIRMA, RBM15/15B, ZC3H13 and HAKAI. These adaptors may help in determining the specific sites of m6A methylation. For example, VIRMA mediates preferential m6A mRNA methylation in the 3'UTR, while HAKAI affects m6A modification distributed in the 5’UTR. b m6A in 28S and 18S rRNA is the result of ZCCHC4 and METTL5-TRMT112 complex activity, respectively. c METTL16 mediates m6A modification in U6 snRNA and a small proportion of other mRNAs through specific structural recognition