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Table 1 Chi-square test in male cohort calculated for all ages (a); for age ≥ 50 years (b); and combination of AR poly-Q ≥ 23 and D-dimer value (c)

From: SELP Asp603Asn and severe thrombosis in COVID-19 males

a

Severe (%)

Mild (%)

Marginal row totals

Chi-square test in male cohort (all ages)

Asn/Asn genotype

90 (38.14)

59 (21.30)

149

Asp/Asp and Asp/Asn genotype

146 (61.86)

218 (78.70)

364

Marginal column totals

236 (100)

277 (100)

513 (grand total)

b

Severe (%)

Mild (%)

Marginal row totals

Chi-square test in males ≥ 50 years

Asn/Asn genotype

73 (39.25)

40(21.05)

113

Asp/Asp and Asp/Asn genotype

113 (60.75)

150 (78.95)

263

Marginal column totals

186 (100)

190 (100)

376 (grand total)

c

D-dimer > 5000

D-dimer < 5000

Marginal row totals

Chi-square test of combination of AR poly Q ≥ 23 and D-dimer value

Asn/Asn and AR polyQ ≥ 23

10

19

29

Asp/Asp and Asp/Asn and AR poliQ < 23

40

248

288

Marginal Column totals

50

267

317 (grand total)

  1. p value (severe vs mild) = 2.8 × 10–5 (OR 2.27, 95% CI 1.54–3.36)
  2. p value (severe vs mild) = 1.19 × 10–4 (OR 2.42, 95% CI 1.53–3.82)
  3. p value (D-dimer > 5000 vs D-dimer < 5000) = 3.73 × 10–3 (OR 3.26, 95% CI 1.41–7.52)