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Table 1 Chi-square test in male cohort calculated for all ages (a); for age ≥ 50 years (b); and combination of AR poly-Q ≥ 23 and D-dimer value (c)

From: SELP Asp603Asn and severe thrombosis in COVID-19 males

a Severe (%) Mild (%) Marginal row totals
Chi-square test in male cohort (all ages)
Asn/Asn genotype 90 (38.14) 59 (21.30) 149
Asp/Asp and Asp/Asn genotype 146 (61.86) 218 (78.70) 364
Marginal column totals 236 (100) 277 (100) 513 (grand total)
b Severe (%) Mild (%) Marginal row totals
Chi-square test in males ≥ 50 years
Asn/Asn genotype 73 (39.25) 40(21.05) 113
Asp/Asp and Asp/Asn genotype 113 (60.75) 150 (78.95) 263
Marginal column totals 186 (100) 190 (100) 376 (grand total)
c D-dimer > 5000 D-dimer < 5000 Marginal row totals
Chi-square test of combination of AR poly Q ≥ 23 and D-dimer value
Asn/Asn and AR polyQ ≥ 23 10 19 29
Asp/Asp and Asp/Asn and AR poliQ < 23 40 248 288
Marginal Column totals 50 267 317 (grand total)
  1. p value (severe vs mild) = 2.8 × 10–5 (OR 2.27, 95% CI 1.54–3.36)
  2. p value (severe vs mild) = 1.19 × 10–4 (OR 2.42, 95% CI 1.53–3.82)
  3. p value (D-dimer > 5000 vs D-dimer < 5000) = 3.73 × 10–3 (OR 3.26, 95% CI 1.41–7.52)