Fig. 10
From: Protein degradation technology: a strategic paradigm shift in drug discovery
a Schematic diagram of the mechanism of HaloPROTAC. In the HaloPROTAC molecule, the yellow triangle connected to the hydroxyl group represents the VHL ligand (hydroxyproline derivative), and the moiety in the red dashed circle represents the chlorinated alkanes. The two parts are connected by a linker. b Structures of the VHL ligand VL285 and two effective HaloPROTAC molecules. c Schematic diagram of the specific mechanism of TRAFTAC