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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response

Fig. 3

The effects of monocyte depletion on BsAb directed T cell immunotherapy. A Neuroblastoma PDX bearing mice were treated by GD2-BsAb armed T cells (GD2-EATs) with anti-Ly6C antibody to deplete monocytes. B Peripheral blood (PB) was analyzed by CBC and compared among groups. C Tumors harvested on day 10 were analyzed by flow cytometry (Additional file 1: Fig. S3), and the frequencies of each tumor infiltrating leukocytes were compared among groups. D Immunohistochemical (IHC) staining of tumor sections by anti-human CD3 antibody (× 10), anti-human CD4 antibody (× 10), anti-CD8 antibody (× 10), and anti-mouse IBA1 antibody (× 10). The tumors were harvested on day 10 after the start of treatment

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Journal of Hematology & Oncology

ISSN: 1756-8722

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