Fig. 4
From: Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target
Schematic representation of the mechanism by which tumor cells become resistant to anti-PD-1/PD-L1 antibodies via the FGL1/LAG3 pathway. a The PD-1/PD-L1 pathway inhibits the toxic effects of T cells on tumor cells. b The addition of anti-PD-1/PD-L1 antibodies restores the toxic effect of T cells on tumor cells. c The FGL1/LAG3 pathway inactivates T cells, and tumor cells become resistant to anti-PD-1/PD-L1 antibodies once again