Fig. 1

In vivo confocal microscopy of the peripheral and central cornea at various depths, according to belamaf ocular toxicity stage. Before being able to note any clinical signs or vision loss, a high density of hyperreflective deposits is detected specifically in the deeper layers of the peripheral cornea (red square for high density in the sub-Bowman’s layer and an orange square for low density in the basal epithelium). At more severe stages (clinical signs, vision loss), hyperreflective deposits are detected in every layer and peripheral and central areas. Deep deposits appear as a “bunch of grapes” shaped lesions, which transform into round intraepithelial microcysts the closer they go to the surface