Fig. 4From: Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiationIntegrative RNA and methylation analyses of T-LUAD and T-LUSC versus their control counterparts. a Pathway enrichment analyses on the DEGs of the T-LUAD versus LUAD comparison. b Pathway enrichment analyses on the DEGs of the T-LUSC versus de novo LUSC comparison. c Scatter plots showing differentially expressed genes exhibiting differential methylation levels in T-LUSC versus de novo LUSC comparison, grouped by pathways of interest. Significantly differentially expressed (q value < 0.05 and [beta] >  = log2(1.2)) and methylated (FDR < 0.05 and differential methylation level greater than 0.1) sites are highlighted. Those genes where increased gene body or promoter methylation is correlated with expression positively and negatively, respectively, are labeledBack to article page