Table2 Integrins function as CSC markers in different solid cancers

β4

TNBC

Identifies a CSC-enriched population with partial mesenchymal traits

[78]

PDAC

High level of β4 expression significantly correlates with stemness and EMT

[79]

Prostate

Sustains the self-renewal of putative CSCs and promotes tumorigenesis by amplifying ErbB2 and c-Met signaling in tumor progenitor cells

[80]

α6

Glioblastoma

Co-expresses with conventional glioblastoma CSC markers and enriched for CSCs

[54]

α7

OSCC

Identifies a CSC-enriched population with elevated expression of SC genes and EMT features. The α7 co-expresses with the traditional CSC marker CD90 but further stratifies and marks a more tumorigenic subset

[56]

β3

Breast

A luminal epithelial progenitor marker that identifies a CSC population in mouse models of mammary tumorigenesis

[81]

β8

Glioblastoma

Overexpresses in and maintains glioblastoma CSC, and its overexpression induces radio-resistance and is correlated with poor prognosis

[82]

αvβ3

Breast

Regulates adult mammary SCs during pregnancy, and activates Slug in BCa cells to increase CSC features such as tumorsphere formation and tumor initiation

[83]

α6 and β3

Breast

α6^highβ3^high identifies a CSC-enriched population with enhanced tumorsphere formation and drug resistance to pacitaxel and doxorubicin in mouse Her2/neu transgenic breast tumors

[55]

α2β1

NSCLC

Exosomes derived from NSCLC cells carrying low levels of miR-34c-3p induce upregulation of α2β1, which promotes cancer cell invasion and migration

[84]

Colon

Enhances metastatic capability and stemness of colorectal cancer cells via PI3K/AKT/Snail axis

[85]

β1

HNSCC

Promotes stemness, chemoresistance and tumor-forming capacity of cancer cells

[86]

OSCC

Overexpresses in stem-like cancer cells and enhances cell proliferation, migration and tumorsphere formation

[87]