Dysregulated tumor-associated macrophages in carcinogenesis, progression and targeted therapy of gynecological and breast cancers

Table 2 TAMs markers

TAM marker	Tumor type	Function	References
CD68	Breast cancer	The expression of CD68 was negatively correlated with ERα or progesterone receptor	[7]
CD14, CD163	Cervical cancer	CD14⁺CD163⁺macrophages have poor ability to stimulate T cell proliferation and produce INF-γ	[34]
CD163, CD204	Ovarian cancer	Tumor-derived CSF-1 may induce CD163⁺CD204⁺M2 differentiation	[42]
Arg-1, CD206, iNOS, CD86	Endometrial cancer	Endometrial cancer cells induced high expression of Arg-1 and CD206 and low expression of iNOS and CD86 on TAMs	[43]
CD163	Cervical cancer	Hypoxia is positively associated with CD163⁺TAM infiltration and cervical cancer progression	[45]
CD163, CD206	Breast cancer	mTORC2 mediated CD163⁺CD206⁺M2 polarization of macrophages in hypoxic TME	[47]
CD206	Endometrial cancer	Endometrial cancer cells promoted CD206⁺M2-like macrophage polarization	[48]

ISSN: 1756-8722